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Non-Steroidal Anti-Inflammatory Drugs
van Himbergen, 2012
Framingham Heart Study
Average Follow-up Time Detail
The cohort was followed for a median of 13 years. All confirmed cases of dementia after the 19th biennial examination (through December 31, 2009) were included, providing longitudinal follow-up of up to 24 years.
levels were measured in plasma on an Olympus AU400 with enzymatic reagents as reported elsewhere (34-36). Interassay coefficients of variation were less than 5% for all assays.
We calculated the weighted mean Lp-PLA
level at baseline, as means were provided for men and women separately in Table 1.
No race or ethnicity information provided in report.
According to a
of the cohort, nearly all the members of the original cohort were Caucasian.
The mean age at start of follow-up is actually the age at the 19th biennial examination (1985-1988). We calculated a weighted average of the mean age, as the age is provided separately for men and women in Table 1.
Screening and Diagnosis Detail
Mini-Mental State Examination (Folstein 1975)
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition
: "Members of the dementia cohort have been monitored for the development of stroke and dementia since their inclusion in the cohort. Participants were routinely administered a screening Mini-Mental State Examination at each biennial examination . Persons who scored less than education-based cutoffs or who experienced a decline of 3 or more points on the Mini-Mental State Examination from the most recent previous examination were called back for a neurological and neuropsychological examination. For each case of possible dementia, a detailed case review was undertaken by a panel consisting of at least 1 neurologist (including P.A.W. and S.S.) and a neuropsychologist (R.A.). The panel determined the type of dementia and the date of diagnosis using serial neurological and neuropsychological assessments, a telephone interview with a family member or a caregiver, medical records, and imaging study results. The diagnosis of dementia was made according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition . Alzheimer disease was diagnosed when subjects met the criteria of the National Institute of Neurological Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association for definite, probable, or possible AD ."
Covariates & Analysis Detail
Cox proportional hazards regression