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Non-Steroidal Anti-Inflammatory Drugs
Manitoba Study of Health and Aging
Average Follow-up Time Detail
Selected participants were initially screened for cognitive impairment in 1991 or 1992. Those who were considered free of cognitive impairment at baseline (3MS score of 78+) formed the incidence cohort and were reevaluated in 1996 or 1997.
Information on NSAID use was obtained through self report via a mailed questionnaire.
According to other
of the cohort, participants were recruited from a stratified random sample of Manitoba, Canada residents ages 65 and older. No information on the ethnic background of participants has been provided.
Participants 75 years or older were oversampled during initial cohort formation.
Screening and Diagnosis Detail
"Modified" Modified Mini-Mental State Examination (Tschantz 2002)
Modified Mini-Mental State Examination (Teng 1987)
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Cognitive impairment was assessed using the Modified Mini-Mental State Exam (3MS).
Individuals scoring less than 78 out of a possible 100 were considered to be potentially cognitively impaired and were invited to participate in a clinical assessment which included neuropsychological testing as appropriate. The diagnostic categories of probable and possible AD were assigned based on this clinical assessment according to National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria,
the standard clinical research protocol for diagnosis of AD."
Covariates & Analysis Detail