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AlzRisk Paper Detail
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Reference: Middleton, 2007
Cohort: Canadian Study of Health and Aging
Risk Factor: B Vitamins


Ethnicity Detail
The cohort is a representative sample of Canadian men and women aged 65 and older living in urban and rural Canada from all 10 provinces.

Screening and Diagnosis Detail
Screening Method:
3MSEModified Mini-Mental State Examination (Teng 1987)

AD Diagnosis:
DSM IIIR Diagnostic and Statistical Manual III-Revised

Total dementia definition: Dementia via DSM-III-R.

"The community sample was screened using the Modified Mini-Mental State Examination (3MS)[13]. People who screened positive (3MS score
<78; n=1,165) and a random sample who scored greater than 77 (n=494) were examined clinically, as were all institutionalized respondents. A nurse, physician, and neuropsychologist made assessments[14]. Diagnoses were made at a consensus conference, using the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised criteria."

Covariates & Analysis Detail
Analysis Type:
Logistic regression

AD Covariates:
Aage
Eeducation
Ggender
PAphysical activity
VARSvascular risk score
VTBvitamin B12

TD Covariates:
Aage
Eeducation
Ggender
PAphysical activity
VARSvascular risk score
VTBvitamin B12