Get Newsletter
AlzRisk Paper Detail
Back

Reference: Nelson, 2009
Cohort: Cache County Study
Risk Factor: B Vitamins


Exposure Detail
Dietary intake was measured at baseline using a 142-item self-administered food frequency questionnaire (FFQ) that included a section on dietary supplement usage.

The article reports two figures for the total number of AD cases (202 and 212).

Ethnicity Detail
Participants included residents residing in Cache County, Utah. No other information on ethnicity was reported.

Screening and Diagnosis Detail
Screening Method:
3MSEModified Mini-Mental State Examination (Teng 1987)

AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Total dementia definition: Dementia via DSM-III-R.

"Participants who scored lower than 87 on the 3MS and all subjects older than 90 years of age were further assessed for cognitive status using multi-staged clinical assessments of cognitive status. The clinical data included results from the Dementia Questionnaire (DQ) (15) and a clinical assessment conducted in the participant’s home or place of residence. The DQ is an inventory of cognitive
symptoms, functional impairments, and medical conditions relevant to dementia and was administered by trained nurses. The clinical evaluations were reviewed by a geropsychiatrist and a neuropsychologist, who assigned dementia diagnoses. Participants initially assigned a dementia diagnoses were further examined and completed a magnetic resonance imaging scan and additional laboratory tests. Final diagnoses were obtained via a consensus conference of clinical experts."

The article reports two figures for the total number of AD cases (202 and 212).

Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression

Age was the time scale in the proportional hazards analysis.

AD Covariates:
Aage
Eeducation
Ggender
ALCalcohol intake
APOE4APOE e4 genotype
BMIbody mass index
Kcalcaloric intake
DMdiabetes mellitus
MImycardial infarction history
PAphysical activity
SMsmoking status
SHstroke history
FOLTOTLtotal folate
VTBvitamin B12
§ Covariates for total dementia are different.

TD Covariates:
Aage
Eeducation
Ggender
ALCalcohol intake
APOE4APOE e4 genotype
BMIbody mass index
Kcalcaloric intake
DMdiabetes mellitus
MImycardial infarction history
PAphysical activity
SMsmoking status
SHstroke history
VTBvitamin B12
VTB6vitamin B6