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AlzRisk Paper Detail

Reference: Morris, 2005
Cohort: Chicago Health and Aging Project
Risk Factor: Nutritional Antioxidants

Average Follow-up Time Detail
We estimated person-years of follow-up by multiplying the reported median follow-up by the number of participants.

Exposure Detail
Dietary intake of vitamin E was evaluated using a modified version of the Harvard food frequency questionnaire (FFQ), which was administered at a median of 1.2 years after the baseline cognitive interview. The questionnaire addressed food consumption during the past year. Nutrient intakes were adjusted for total energy intake using the regression residual method (Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124:17-27), and it was these calorie-adjusted intakes that were used in the analyses of vitamin E and AD.

Screening and Diagnosis Detail
AD Diagnosis:
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Screening and Diagnosis Detail: Investigators did not "exclude as cases persons who met the criteria but had another coexisting condition that was thought to contribute to dementia."

Covariates & Analysis Detail
Analysis Type:
Logistic regression

AD Covariates:
APOE4APOE e4 genotype
FUTfollow up time
SSstratified sampling

Analysis also included frequency of participation in cognitive activities, intakes of saturated fat, trans unsaturated fat, docosahexaenoic acid, and an interaction term between race and APOE e4.

Nutrient intakes were adjusted for total energy intake using the regression residual method.