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AlzRisk Paper Detail
Risk Factors
Alcohol
B Vitamins
Blood Pressure
Cognitive Activity
Diabetes Mellitus
Dietary Pattern
Head injury
Homocysteine
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Inflammatory Biomarkers
Non-Steroidal Anti-Inflammatory Drugs
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Statin use
Reference:
Sparks, 2008
Cohort:
Alzheimer's Disease Anti-inflammatory Prevention Trial
Risk Factor:
Statin use
Average Follow-up Time Detail
Members of the cohort were followed for up to 3.75 years. The article does not provide the average follow-up time for the participants.
Exposure Detail
The interviewers ascertained exposure by recording self-reported statin use at each visit.
The investigators compared incident AD risk in two groups: the group of participants who consistently used statins during follow-up ("Consistently used") and the reference group of participants who did not use statins or non-statin LLAS ("Never used").
Ethnicity Detail
The participants of the ADAPT trial were predominantly Caucasian (97%). Few participants were African-American. The article did not report the ethnicity breakdown of the sample used for this analysis.
Screening and Diagnosis Detail
Screening Method:
Brain Imaging
CAB
Cognitive Assessment Battery Testing
Informant interview
LAB
Laboratory Testing
MMSE
Mini-Mental State Examination (Folstein 1975)
Neuropsych Testing
Other
AD Diagnosis:
DSM IV
Diagnostic and Statistical Manual IV
NINCDS ADRDA
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition:
Dementia via DSM-IV
Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression
AD Covariates:
A
age
E
education
G
gender
APOE4
APOE e4 genotype