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AlzRisk Paper Detail

Reference: Fischer, 2008
Cohort: Vienna Trans-danube Aging Cohort
Risk Factor: Non-Steroidal Anti-Inflammatory Drugs

Average Follow-up Time Detail
The study follow-up period was 30 months.

Exposure Detail
Investigators ascertained exposure information through a structured interview and self-report at baseline and follow-up.

The investigators compared incident AD risk in three groups: the group of participants who used any NSAIDs for at most two years ("≤ 2 years") at baseline, the group of participants who used any NSAIDs for more than two years ("> 2 years") at baseline, and the reference group of participants who did not use any NSAIDs ("Non- use") at baseline.

Ethnicity Detail
The study cohort included inhabitants of Vienna, Austria. The distribution of ethnicity was not reported.

Age Detail
The study cohort included 75-year-old inhabitants of Vienna, Austria who were born between May 1925 and June 1926, who were alive on May 1st, 2000.

Screening and Diagnosis Detail
Screening Method:
CERADConsortium to Establish a Registry for Alzheimer's Disease (Morris 1989)

AD Diagnosis:
DSM IV Diagnostic and Statistical Manual IV
NINCDS ADRDA National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)

Covariates & Analysis Detail
Analysis Type:
Logistic regression

"Ordinal logistic regressions were calculated in order to investigate the univariate influence of risk factors on the 3 classes of outcome: no AD, possible AD or probable AD. The probability of being in a higher category was modelled, e.g. the odds ratio (OR) of the healthy versus the possible or probable group. OR and 95% confidence intervals (CI) are reported. Only risk factors with a p value < 0.05 were further applied in a stepwise multivariate ordinal logistic regression where the probability to enter or to stay was set at 0.05."